[Cu]-catalyzed direct coupling of dibromoalkenes: Synthesis of symmetrical 1,3-diynes and triazoles

ABSTRACT

An efficient [Cu]-catalyzed homocoupling of 1,1-dibromoalk-1-enes is described for the synthesis of symmetrical 1,3-diyines. The method showed good substrate scope and amenable to aryl and heteroaryl systems. Significantly, the strategy was also successfully applied to the sequential one-pot synthesis of triazoles.

GRAPHICAL ABSTRACT

KEYWORDS:

• Copper catalysis
• 1,1-dibromo alkenes
• 1,3-diynes
• homo-coupling
• triazoles

Acknowledgments

L. M. and B. V. R. thanks CSIR, New Delhi for the award of research fellowship. Thanks to Dr William P. Unsworth (University of York, UK) for his support.