Facile synthesis of novel dihydroquinoline-3,3-dicarbonitriles in the presence of glacial acetic acid as a catalyst under solvent-free conditions

ABSTRACT

A series of novel dihydroquinoline derivatives were synthesized using malononitrile, 2-aminobenzoic acid, and benzaldehydes in the presence of a catalytic amount of acetic acid, without the use of any additional cocatalyst, under solvent-free conditions. The reaction is characterized by high efficiency, easy workup, simple purification of the products, and availability of catalyst.

GRAPHICAL ABSTRACT

KEYWORDS:

• Acetic acid
• 2-aminobenzoic acid
• dihydroquinoline derivatives
• malononitrile
• solvent free

Acknowledgment

We are grateful to the Yasouj University for supporting this work.