Phenacyl bromide: A versatile organic intermediate for the synthesis of heterocyclic compounds

ABSTRACT

Phenacyl bromides are used as a building blocks in synthetic organic chemistry, which serves as a key model for the development of various biologically important heterocyclic compounds and other industrially important scaffolds. This review covers recent synthetic advances in the preparation of heterocyclic compounds utilizing various phenacyl bromides. A wide range of five- and six-membered heterocyclic compounds as well as fused heterocyclic compounds were synthesized efficiently from the phenacyl bromide precursors through one-pot multicomponent reactions.

GRAPHICAL ABSTRACT

KEYWORDS:

• Five-membered heterocyclic
• fused heterocyclic compound
• multicomponent reactions
• one-pot reaction
• phenacyl bromides
• six-membered heterocyclic

Acknowledgments

The authors are thankful to the Department of Chemistry, Gujarat University, Ahmedabad, for providing the necessary facilities. UGC-Info net and INFLIBNET Gujarat University are acknowledged for providing the e-source facilities.