http://orcid.org/0000-0002-6748-3663
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ABSTRACT
A one-pot, three-component protocol for the synthesis of novel five-membered thiazole ring bonded to two hydrazone motifs is described. The acid-catalyzed reaction of one equivalent of thiocarbohydrazide, two equivalents of aromatic aldehydes, and one equivalent of phenacyl bromides afforded the five-membered thiazole ring. The reactions proceed with novel chemoselectivity. Similar reported protocols have always afforded 1,3,4-thiadiazines.
GRAPHICAL ABSTRACT
Acknowledgment
Hasan Tashtoush thanks Jordan University of Science and Technology for his sabbatical stay.
Additional information
Funding
The financial support of this work by the Deanship of Graduate Studies and Research at Yarmouk University is highly acknowledged (project no. 29/2014).