CAN-catalyzed microwave promoted reaction of indole with Betti bases under solvent-free condition and evaluation of antibacterial activity of the products

ABSTRACT

CAN-catalyzed reaction of Betti bases with indoles under microwave irradiation gives 3-(α,α-diarylmethyl)indoles. Better yield of the products, especially when one of the aryl ring is phenol were achieved. The reaction is performed in solvent-free condition. The antibacterial studies of the synthesized compounds were performed and some of the compounds showed good activity against Methicillin-resistant Staphylococcus aureus bacteria.

GRAPHICAL ABSTRACT

KEYWORDS:

• Betti base
• CAN-catalyzed
• 3-(α,α-diarylmethyl)indoles
• microwave
• solvent-free

Additional information

Funding

Mohit L. Deb is thankful to the Science and Engineering Research Board (SERB), India, for financial support (Grant No. SB/FT/CS-073/2014) under the Fast Track Scheme. Pranjal K. Baruah is thankful to the SERB, New Delhi, India (Grant No. SB/FT/CS-100/2012) for financial support.