One-pot multi-component synthesis of N,N′-alkylidene bisamides and imidazoles using heteropoly-11-tungsto-1-vanadophosphoric acid supported on natural clay as catalyst: A green approach

ABSTRACT

One-pot multi-component synthesis of N,N′-alkylidene bisamides, 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles in the presence of catalytic material heteropoly-11-tungsto-1-vanadophosphoric acid (HPV) supported on activated natural clay for about 20% (HPVAC-20) under solvent-free reaction condition have been achieved. Green heterogeneous reaction condition, simple workup procedure, short reaction time, high yield of products, and reusability of the catalyst are the advantages of this protocol.

GRAPHICAL ABSTRACT

KEYWORDS:

• Bisamides
• heteropoly acid
• imidazoles
• multi-component synthesis
• natural clay

Acknowledgments

The authors Ponnusamy Sami and Karuppaiah Selvakumar thank University Grants Commission, New Delhi, India, for the award of major research project (F. No. 42-349/2013(SR)) and financial assistance. We also thank Managing Board, VHNSN College, Virudhunagar for infrastructural facilities.

Additional information

Funding

This research was supported by University Grants Commission, New Delhi, India. F. No. 42-349/2013(SR).