ABSTRACT
The total synthesis of 14-membered resorcylic acid macrolide, β-zearalenol, was accomplished starting from commercially available enantiomerically pure propylene oxide and methyl 2,4-dihydroxy-6-methylbenzoate using Grignard reaction, asymmetric dihydroxylation, Yamaguchi macrolactonization, and ring-closing metathesis as key steps.
GRAPHICAL ABSTRACT
Acknowledgments
The authors are thankful to GVK Bio Sciences and CSIR, New Delhi for constant encouragement in providing laboratory facilities and analytical data.