Total synthesis of patulolide A through ring closing metathesis

ABSTRACT

A simple and efficient total synthesis of patulolide A from readily available 7-octen-1-ol is reported by asymmetric synthetic approach. The key reactions involved are asymmetric dihydroxylation using AD-mix-β and Grubbs’ ring-closing metathesis reaction for the synthesis macrocyclic ring system.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1,3-Dithiane
• AD-mix
• patulolide A
• ring closing metathesis

Acknowledgment

The authors are thankful to GVK Bio Sciences and CSIR, New Delhi for constant encouragement in providing laboratory facilities and analytical data.