ABSTRACT
A simple and efficient total synthesis of patulolide A from readily available 7-octen-1-ol is reported by asymmetric synthetic approach. The key reactions involved are asymmetric dihydroxylation using AD-mix-β and Grubbs’ ring-closing metathesis reaction for the synthesis macrocyclic ring system.
GRAPHICAL ABSTRACT
Acknowledgment
The authors are thankful to GVK Bio Sciences and CSIR, New Delhi for constant encouragement in providing laboratory facilities and analytical data.