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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 2
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Original Articles

Four component synthesis of highly functionalized pyrano[2,3-c]pyrazoles from benzyl halides

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Pages 146-154 | Received 25 Jun 2017, Published online: 22 Dec 2017
 

ABSTRACT

N-methylmorpholine N-oxide and silver oxide (Ag2O) oxidized four component reaction for the preparation of pyranopyrazole with different substituted pattern have been developed which provides rapid access to a library of compounds in good to excellent yields by using benzyl halide, malanonitrile/ethyl cyanoacetate, diethylacetylenedicarboxylate/ethyl acetoacetate and hydrazine hydrate as reactants. This transformation involves the breaking of one C‒O bond and formation of 2 C–C, 2 C–N, and a C‒O bond leading to the formation of a five and six membered ring in one pot operation.

GRAPHICAL ABSTRACT

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