Greener approach toward the generation of dimedone derivatives

ABSTRACT

The use of dimedone in green chemistry has been described for the synthesis of selective heterocyclic motifs which are both pharmacologically and industrially important. The objective of this review is to summarize some of the selected recent advances of dimedone in the synthesis of organic compounds utilizing green chemistry procedures.

GRAPHICAL ABSTRACT

KEYWORDS:

• Aqueous conditions
• catalyst-mediated
• dimedone
• environment-friendly
• green chemistry
• heterocyclic compounds
• ionic liquid
• magnetically reusable organocatalyst
• multicomponent reactions
• nanoparticles
• recyclable
• reusable
• solvent-free
• solvent-mediated

Abbreviations::

• (AlKIT-5): 3D aluminum-supported mesoporous KIT-5 material; DABCO: diazabicyclo[2.2.2] octane; DBSA: p-dodecyl benzenesulfonic acid
• DBU: 1,8-diazabicyclo[5.4.0]undec-7-ene
• DDBSA: dodecyl benzene sulfonic acid
• DMAP: dimethylamino pyridine
• ([DMDBSI] · 2HSO₄): 1,3-dimethyl-2-oxo-1,3-bis(4-sulfobutyl)imidazolidine-1:3-diium hydrogen sulphate
• DMF: dimethylformamide
• DMSO: dimethylsulfoxide
• EDDA: ethylene diamine diacetic acid
• γ-Fe₂O₃@HAP-SO₃H: hydroxyapatite-encapsulated-γ-Fe₂O₃-supported sulfonic acid nanoparticles
• HPA: heteropolyacid
• INH: isoniazid
• MDC: methylene dichloride
• MDR-TB: multidrug-resistant Mycobacterium tuberculosis
• MTB: Mycobacterium tuberculosis H37Rv
• nano-SiO₂–Cl: silica chloride nanoparticle
• NBS: N-bromosuccinimide
• NCS: N-chlorosuccinimide
• NPs: nanoparticles
• p-TSA: p-toluene sulfonic acid
• PEG-SO₃H: sulfonated polyethylene glycol
• SAFIS: sulfonic acid-functionalized imidazolium salts
• (SB-DBU)Cl: silica-bonded 5-n-octahydro-pyrimido[1,2-AQ]azepinium chloride
• SDS: sodium dodecyl sulfate
• SEM: scanning electron microscope
• TBAF: tetrabutyl ammonium fluoride
• TEBA: benzyltriethyl ammonium chloride
• TEM: transmission electron microscopy
• TOF: turn over frequency
• TON: turn over number
• XRD: X-ray diffraction

Acknowledgment

The authors are thankful to Prof. Aditya Shastri, Vice Chancellor, Banasthali University for providing support and facilities to our work.