De novo synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazolin-4(1H)-one compounds

ABSTRACT

A new versatile and efficient strategy for the synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazoline-4(1H)-one compounds has been developed by one-pot multicomponent reaction with isatoic anhydride, amines followed by in situ-generated Vilsmeier reagent. The reaction has also been studied with different amines and solvents.

GRAPHICAL ABSTRACT

KEYWORDS:

• 2,2-Bis(dimethylamino)-3-alkyl or benzyl 2,3-dihyroquinazoline-4(1H)-one
• annulation
• isatoic anhydride
• oxalyl chloride
• Vilsmeier reagent

Acknowledgment

The authors would like to thank Dr. Reddy’s Laboratories Limited for the encouragement.