Organocatalytic mediated green approach: A versatile new L-valine promoted synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans

ABSTRACT

The discovery of a new L-valine promoted facile and versatile green synthesis of diversified 2-amino-3-cyano-4H-pyrans using a one pot multicomponent-tandem reaction of aromatic aldehydes, malononitrile, and diverse electron-rich enolizable carbonyl compounds is described. To the best of our knowledge this is the first report on the use of native L-valine as a catalyst in organic synthesis. Environmental friendly, mild reaction conditions, use of easily available inexpensive starting materials, short reaction time, excellent yields, high atom economy, and recyclability of organocatalyst are the major advantages of the disclosed protocol.

GRAPHICAL ABSTRACT

KEYWORDS:

• 2-Amino-3-cyano-4H-pyrans
• L-valine
• green synthesis
• multicomponent
• water

Additional information

Funding

The authors are thankful to SAIF, PU, Chandigarh for spectral data. The authors also acknowledge the financial support from UGC, New Delhi in form of fellowships for Fatima Tufail and Amit Kumar Sharma. Jyoti Tiwari and Shailesh Singh thank CSIR, New Delhi for SRF and JRF, respectively.