Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 3
Submit an article Journal homepage
1,251
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Deprotection of durable benzenesulfonyl protection for phenols — efficient synthesis of polyphenols

Mohammad Shariful AlamDepartment of Energy Science and Technology, Myongji University, Yongin, Korea
&
Sangho KooDepartment of Energy Science and Technology, Myongji University, Yongin, Korea;Department of Chemistry, Myongji University, Yongin, KoreaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-4725-1117
ORCID Icon
Pages 247-254 | Received 10 Sep 2017, Published online: 02 Jan 2018
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

ABSTRACT

A robust protection method for phenol was demonstrated by the use of durable benzenesulfonyl group, which survives various harsh reaction conditions using Grignard reagent, organolithium reagent, metal alkoxide, phosgene, mineral, and Lewis acids. A facile deprotection condition utilizing pulverized KOH (5 equiv) and t-BuOH (10 equiv) in hot toluene makes this protocol as a practical method, which can be applied to the multistep synthesis of biologically and medicinally important polyphenol compounds.

GRAPHICAL ABSTRACT

Acknowledgement

This work was supported by 2017 research fund of Myongji University.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.