Novel one-pot expeditious synthesis of 2,4-disubstituted thiazoles through a three-component reaction under solvent free conditions

ABSTRACT

An expeditious one pot method has been developed for the synthesis of 2,4-disubstituted thiazoles under solvent free conditions via a multicomponent approach. Substituted thiazoles were synthesized with high yields by the reaction of cyclic ketones, thiosemicarbazide, and phenacyl bromides or 3-(2-bromoacetyl)-2H-chromen-2-ones in a shorter reaction time with high purity via simple purification technique.

GRAPHICAL ABSTRACT

KEYWORDS:

• 2,4-Disubstituted thiazoles
• cyclic ketones
• cyclocondensation
• multicomponent reactions
• phenacyl bromides
• thiosemicarbazone

Acknowledgments

The authors are thankful to the Director, National Institute of Technology, Warangal, Telangana, India for providing the facilities. K. S. thanks to the MHRD, India for fellowship.