ABSTRACT
An expeditious one pot method has been developed for the synthesis of 2,4-disubstituted thiazoles under solvent free conditions via a multicomponent approach. Substituted thiazoles were synthesized with high yields by the reaction of cyclic ketones, thiosemicarbazide, and phenacyl bromides or 3-(2-bromoacetyl)-2H-chromen-2-ones in a shorter reaction time with high purity via simple purification technique.
GRAPHICAL ABSTRACT
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Acknowledgments
The authors are thankful to the Director, National Institute of Technology, Warangal, Telangana, India for providing the facilities. K. S. thanks to the MHRD, India for fellowship.