One-pot three-component tandem reaction: Synthesis of aryl/alkyl cyanamides libraries and their further conversion into tetrazole derivatives

ABSTRACT

We have developed methodology for the synthesis of aryl/alkyl cyanamides from amines in one-pot four steps reaction using cheap, readily available and air stable copper source as catalyst under mild reaction conditions. We have also studied the application of cyanamides. In this connection, we could construct aryl tetrazolamine from cyanamides using click reaction

GRAPHICAL ABSTRACT

KEYWORDS:

• Copper catalyst
• desulphurization
• mild reaction conditions
• room temperature
• substituted cyanamides
• tandem reaction

Acknowledgments

The authors thankful to Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur for providing work space and grateful to UGC for providing Basic Science Research Fellowship (BSRF).