Facile synthesis of TEG-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine and PET imaging agent [F]florbetapir ([F]AV-45)

ABSTRACT

Triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine which can serve as key precursor for many monodentate and multidentate imaging agents for Aβ plaques in human brain has been readily synthesized with cost-effective starting materials. The important non-radioactive monodentate positron emission tomography agent [F]florbetapir ([F]AV-45) has also been prepared by our new method.

GRAPHICAL ABSTRACT

KEYWORDS:

• [F]AV-45
• [F]florbetapir
• Aβ plaques
• PET imaging agent

Additional information

Funding

This work is supported by Fundamental Research Funds for the Central Universities (2016JBM069) and National Science Foundation of China (NSFC 21302011).