Synthesis, characterization, in vitro, and in silico studies of 4-(2′-hydroxybenzoyl) and 4-(2′-hydroxynaphthoyl)-thiabenzene-1-methyl-1-oxides

ABSTRACT

A variety of 4-(2′-hydroxybenzoyl) and 4-(2′-hydroxynaphthoyl) thiabenzene-1-methyl-1-oxides have been prepared by the reaction of dimethylsulfoxoniummethylide with 3-formyl-chromones and screened for their anticancer activities on lung cancer cell line by in vitro and in silico studies.

GRAPHICAL ABSTRACT

KEYWORDS:

• A549 cell line
• Caspase 9
• DIMSOY
• thiabenzene-1-methyl-1-oxides

Acknowledgment

The authors gratefully acknowledge the Amrutanjan Pharmaessense Pvt. Ltd, Chennai, India for analytical support.