CuI/TBHP: A versatile reagent system for the synthesis of 5-iodomethyl-2-aryl-4,5-dihydrooxazoles from N-allylarylamides

ABSTRACT

Herein, a novel reagent system using CuI/TBHP is described for the facile conversion of easily accessible N-allylarylamides into 5-iodomethyl-2-aryl-4,5-dihydrooxazoles in moderate to good yields. In this communication we describe CuI as the iodine source for the first time towards the intramolecular iodooxygenation of N-allylarylamides.

GRAPHICAL ABSTRACT

KEYWORDS:

• 5-Dihydrooxazoles
• 5-iodomethyl-2-aryl-4
• intramolecular cyclization
• N-allylarylamides

Additional information

Funding

KN and NR thank CSIR New Delhi for research fellowships. This research work was financially supported by the CSIR, New Delhi (BSC 0116).