An expedient synthesis of spirooxindoles incorporating 2-amino pyran-3-carbonitrile unit employing dialkyl acetone-1,3-dicarboxylates

ABSTRACT

Spirooxindoles are a class of molecules possessing significant biological effects such as antiviral, antifungal, antibacterial and anticancer properties. Herein we report a series of spirooxindole molecules having 2-amino pyran-3-carbonitrile and with two ester groups. These molecules were prepared by the reaction of dialkyl acetone-1,3-dicarboxylate and isatilidenes in the presence of triethyl amine.

GRAPHICAL ABSTRACT

KEYWORDS:

• 2-Amino pyran-3-carbonitrile
• dialkyl 1,3-acetone dicarboxylates
• isatilidenes
• spirooxindoles
• tricarbonyl compounds

Acknowledgments

The authors acknowledge SICC, University of Kerala for spectral and elemental analysis. A. L. B. thank the UGC for Junior Research fellowship.