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ABSTRACT
This work is focused on the development of a convenient and efficient approach for the synthesis of furoquinolinones and furopyridinones through palladium-catalyzed cyclization reactions between styrenes and 4-hydroxyquinolinones/4-hydroxypyridinones under air conditions. Studies conducted to evaluate the antitumoral potential of the resulted compounds revealed that some of the obtained furoquinolinones exhibited in vitro antiproliferative activity on human-derived stomach cancer cell lines.
GRAPHICAL ABSTRACT
Acknowledgments
Financial support from Open Project of Grain&Corn Engineering Technology Research Center in State Administration of Grain (No. 24400042), Doctor Fund of Henan University of Technology (No. 2013BS053), Colleges and Universities Key Research Program Foundation of Henan Province (No.17A150006), Science and Technology Foundation of Henan Province (No.172102310621), and Fundamental Research Funds for the Henan Provincial Colleges and Universities in Henan University of Technology (No. 2015QNJH08) are greatly appreciated. The authors are also thankful to Jun Liu, Henan University of Technology, for her assistance with NMR analysis.