Recent advances in the synthesis of C-5-substituted analogs of 3,4-dihydropyrimidin-2-ones: A review

ABSTRACT

3,4-Dihydropyrimidin-2-ones act as a versatile scaffold in organic synthesis, which serves as a significant template for the development of various therapeutic agents and shows a wide spectrum of activities. The attractive application of 3,4-dihydropyrimidin-2-ones in organic synthesis is undoubtedly owing to C-5 ester group, which is responsible for the change in its bioactivity. Introduction of various groups like electron-withdrawing and electron-donating groups at positions 1, 2, 3, 5, and 6 greatly increased biological activity. Significant efforts have been undertaken to exploit different synthetic routes to synthesize various derivatives of 3,4-dihydropyrimidin-2-ones. This review article gives a comprehensive account of the synthetic utility of C-5 substitution of 3,4-dihydropyrimidin-2-ones used in the design and synthesis of different types of compounds with greater emphasis on recent literature.

GRAPHICAL ABSTRACT

KEYWORDS:

• 3,4-Dihydropyrimidin-2-ones
• Biginelli reaction
• dihydropyrimidinone
• heterocyclic compounds
• multicomponent reaction
• organic synthesis

Acknowledgments

The authors are thankful to the Department of Chemistry, Gujarat University, Ahmedabad, for providing the necessary facilities and also thankful to UGC-Info net & INFLIBNET Gujarat University for providing e-source facilities. Our special thanks to Dr. Nootan Kotak, Professor of English Department, Gujarat University for valuable English editing for the manuscript.

Additional information

Funding

Sanjay. K. Rathwa (Researcher) is thankful to the UGC-RGNF (RGNF-2014-15-ST-GUJ-60802) for financial assistance.