Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 7
Submit an article Journal homepage
257
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Efficient synthesis of spirooxindole-pyrrolizidines and dispirooxindole-piperazines

Keshri Nath TiwariDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh, IndiaCorrespondence[email protected]
,
Taur Prakash PandurangDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh, India
,
Suyash PantDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh, India
&
P. SreelekhaDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh, India
Pages 802-808 | Received 14 Apr 2017, Published online: 06 Mar 2018
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

ABSTRACT

A simple and efficient approach for the construction of spirooxindole-pyrrolizidines and dispirooxindole-piperazines by cycloaddition reaction of azomethine ylide generated by isatin and proline has been demonstrated successfully. The formation of two different types of frameworks by two different modes of cycloaddition is explored. The developed protocol highlights simple reaction conditions, easy workup processes, and very good yields of products.

GRAPHICAL ABSTRACT

Acknowledgments

We are thankful to Dr. SJS Flora, Director, NIPER, Raebareli for his support and encouragement in carrying out this research work. TPP, SP, and PS are thankful to the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India for providing fellowship. SAIF-CSIR-CDRI, Lucknow is greatly acknowledged for providing spectral data. Communication no. NIPER-R/Communication/034.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.