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ABSTRACT
The efficient and green Brønsted acid or Lewis acid catalysis systems for the Friedländer synthesis of 2,3,4-trisubstituted quinolines from the condensation of 2-aminoarylketones and β-ketoesters/ketones had been developed. The results confirmed that 4-toluenesulfonic acid, magnesium chloride, and cupric nitrate were the desired catalyst independently. This protocol had the advantages of mild conditions, operational simplicity, and excellent yields.
GRAPHICAL ABSTRACT
Additional information
Funding
The work was supported by the Youth Science and Technology Talent Development Project in Education Department of Guizhou Province (Grant No.qianjiaohe KY zi [2017] number 261), the Union Foundation of Science and Technology Department of Guizhou Province (Grant No. qiankehe LH zi [2015] number 7614) and Innovation Team of Liupanshui Normal University (Grant No. LPSSYKJTD201601).