Efficient Mizoroki–Heck coupling reactions using phosphine-modified Pd(II)–picolinate complex

ABSTRACT

Efficient Mizoroki–Heck couplings were obtained using a very easily synthesizable palladium(II) complex of hemilabile N–O ligand (picolinate), with high turnover frequencies up to >10,000 h⁻¹, in just 15 min, with high selectivity of >99% to the desired products. Wide applicability of the simple-looking palladium complex catalyst was established with differently functionalized substrates. Catalyst screening studies revealed intricate details of dependence of catalyst performance on different reaction parameters and conditions and arriving at the optimized facile methodology.

GRAPHICAL ABSTRACT

KEYWORDS:

• Heck coupling
• hemilabile N–O ligand
• homogeneous catalysts
• Pd(II)-complex
• picolinate

Additional information

Funding

S.S. and B.R.S. acknowledge the financial supports from BITS Pilani in the forms of research fellowship and Research Initiation Grant (RIG–06/03/302), respectively. Help from Prof. Satyendra Pandey of Thapar University, India, is gratefully acknowledged.