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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 8
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Original Articles

Synthesis of quinoxalines through iodine-catalyzed one-pot annulation of alkynes with o-phenylenediamines

Jing ZiShanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaView further author information
,
Da-Wei GuShanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaView further author information
,
Yan ZhangShanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaView further author information
,
Zhe-Yao HuShanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaView further author information
,
Xing-Quan ZhangTopsense Safety Technology Consulting Co. Ltd, Shanghai, ChinaView further author information
&
Xun-Xiang GuoShanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaCorrespondence[email protected]
View further author information
Pages 915-920 | Received 09 Aug 2017, Published online: 09 Mar 2018
 
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ABSTRACT

The synthesis of N-heterocycles of quinoxalines has been developed by an efficient protocol of one-pot annulation of alkynes with o-phenylenediamines. A variety of quinoxalines were prepared in good to high yields in the presence of catalytic amount of iodine as a catalyst.

GRAPHICAL ABSTRACT

Additional information

Funding

This work was supported by the Natural Science Foundation of China (No. 21172142).

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