Catalyst-free three-component approach to efficient synthesis of chromeno[4,3-b]pyrrol-4(1H)-one derivatives

ABSTRACT

A mild, efficient, and environmentally benign one-pot synthesis of functionalized chromeno[4,3-b]pyrrol-4(1H)-ones by a three-component domino reaction of 4-aminocoumarins, arylglyoxal monohydrates, and 1,3-dicarbonyl compounds in refluxing ethanol without the use of catalyst is reported. The present protocol features operational simplicity, short reaction time, good yields, and the absence of aqueous workup procedure and chromatographic separation.

GRAPHICAL ABSTRACT

KEYWORDS:

• Catalyst-free
• chromeno[4,3-b]pyrrol-4(1H)-one
• cyclization
• heterocycles synthesis
• multicomponent reaction

Additional information

Funding

We are grateful for the National Natural Science Foundation of China (No. 21676253) for financial support. Cooperation from the colleagues analytical research and development is highly appreciated.