Synthesis of functionalized pyrroles and fused pyrroles through intermolecular [3 + 2] cycloaddition reaction

ABSTRACT

A facile and efficient synthesis of pyrrole and pyrrole-fused heterocyclic compounds has been demonstrated. The current protocol involves the in situ generation of azomethine ylides which undergoes intermolecular cycloaddition reaction and subsequent treatment with DDQ provides the pyrrole and fused heterocyclic compounds in good yields.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1,3-Dipolar intermolecular cycloaddition
• azomethine ylides
• Baylis–Hillman adducts
• DDQ

Additional information

Funding

The authors thank the Council of Scientific and Industrial Research New Delhi, India and University Grants Commission New Delhi, India for financial assistance.