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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 10
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SYNTHETIC COMMUNICATIONS REVIEWS

Synthetic approaches toward the reserpine

, ORCID Icon, , &
Pages 1128-1147 | Received 06 Jan 2018, Published online: 26 Mar 2018
 

ABSTRACT

Reserpine is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms. It was first isolated in 1952 from the dried root of Rauwolfia serpentina whose molecular structure was established in 1953 and natural configuration was published in 1955. The first total synthesis of reserpine was reported by Woodward in 1958. This review article updates current multistep synthetic approaches toward the reserpine natural product and its analogues.

GRAPHICAL ABSTRACT

Additional information

Funding

This work was supported by the Higher Education Commission, Pakistan [Grant Number 5290] and Government College University, Faisalabad & COMSATS Institute of Information Technology, Abbottabad.

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