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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 9
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Original Articles

Green procedure for highly efficient, rapid synthesis of imidazo[1,2-a]pyridine and its late stage functionalization

Prasanjit GhoshDepartment of Chemistry, University of North Bengal, Darjeeling, West Bengal, IndiaView further author information
,
Bhaskar GangulyDepartment of Chemistry, University of North Bengal, Darjeeling, West Bengal, IndiaView further author information
,
Barnali KarDepartment of Chemistry, University of North Bengal, Darjeeling, West Bengal, IndiaView further author information
,
Seema DwivediDepartment of Chemistry, University of North Bengal, Darjeeling, West Bengal, IndiaView further author information
&
Sajal DasDepartment of Chemistry, University of North Bengal, Darjeeling, West Bengal, IndiaCorrespondence[email protected]
View further author information
Pages 1076-1084 | Received 07 Dec 2017, Published online: 26 Mar 2018
 
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ABSTRACT

We unfold a rapid synthetic protocol for the preparation of imidazo[1,2-a]pyridine in cyclohexane. This methodology includes several advantages like shorter reaction time, catalyst free, broader substrate scope, and good yields of the desired products. Late stage functionalization of imidazo[1,2-a]pyridine has also been performed through C–H bond activation and C–C cross-coupling reactions.

GRAPHICAL ABSTRACT

Acknowledgment

PG is thankful to UGC for his fellowship.

Additional information

Funding

We thank the SERB, New Delhi for financial support (EMR/2016/001250).

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