Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 10
Submit an article Journal homepage
226
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Facile and efficient synthesis of quinazoline-2,4(1H,3H)-diones through sequential hydrogenation condensation

Peng-Xu WangState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. ChinaView further author information
,
Ya-Nan WangState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. ChinaView further author information
,
Zi-Yun LinState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. ChinaView further author information
,
Gang LiState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0003-0924-7950View further author information
ORCID Icon &
Hai-Hong HuangState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. ChinaORCID Iconhttp://orcid.org/0000-0003-1641-1309View further author information
ORCID Icon
Pages 1183-1189 | Received 03 Dec 2017, Published online: 26 Mar 2018
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

ABSTRACT

The heterocyclizations from various methyl (2-nitrobenzoyl)carbamates to substituted quinazoline-2,4(1H,3H)-diones under hydrogenation conditions were investigated in this study. In the presence of p-toluenesulfonic acid monohydrate in methanol, various quinazoline-2,4(1H, 3H)-diones were obtained in good to excellent yields within 12 h. The reaction was proposed to proceed through the cascade reactions of nitro reduction and condensation.

GRAPHICAL ABSTRACT

Additional information

Funding

This work was supported by the National Natural Science Foundation of China under Grant 81703362; CAMS Innovation Fund for Medical Sciences under Grant CAMS-2016-I2M-1-010; and Fundamental Scientific Research Fund of Chinese Academy of Medical Sciences under Grant 2016ZX350030.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.