CTAB promoted CuI catalyzed green and economical synthesis of 1,4-disubstituted-1,2,3-triazoles

ABSTRACT

A practical, straightforward, and highly efficient CuI mediated green protocol for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazole was developed using cetyltrimethylammonium bromide as a cheap additive in good to excellent yields. Low catalyst loadings, environmentally friendly solvent, wide substrate scope and short reaction times at room temperature make this strategy more accessible and safe.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1,2,3-Triazoles
• CTAB
• CuAAC
• phase transfer catalyst
• water

Additional information

Funding

D.S. is thankful to DST, New Delhi, India for a research grant [No. EMR/2016/002345]. A.A.A. thanks CSIR, New Delhi for Senior Research Fellowship. The financial assistance of DST-FIST and UGC-SAP programme to the Department of Chemistry, Dibrugarh University is also gratefully acknowledged.