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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 10
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Original Articles

Rapid synthesis of new 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazole as potential antibacterial drugs through one-pot cyclization and Suzuki–Miyaura coupling

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Pages 1213-1219 | Received 26 Jan 2018, Published online: 29 Mar 2018
 

ABSTRACT

Original 2-methyl-7-nitro-5-substituted-2,3-dihydroimidazo[5,1-b]oxazoles were prepared by reacting 1-(2,5-dibromo-4-nitro-1H-imidazol-1-yl)propan-2-ol and various arylboronic acids through “one-pot” cyclization and Suzuki–Miyaura reactions under microwave irradiation.

GRAPHICAL ABSTRACT

Acknowledgment

The authors thank V. Remusat for NMR spectra recording and the Spectropole team for various analytical measurements.

Additional information

Funding

This work was supported by the CNRS (Centre National de la Recherche Scientifique) and Aix-Marseille University.

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