Facile one pot multicomponent synthesis of novel 4-(benzofuran-2-yl)-2-(3-(aryl/heteryl)-5-(aryl/heteryl)-4,5-dihydro-1H-pyrazol-1yl)thiazole derivatives

ABSTRACT

An efficient base catalyzed one pot multicomponent reaction of aryl/hetryl chalcones, thiosemicarbazide and 1-(benzofuran-2-yl)-2-bromoethan-1-one was developed to synthesize the novel 4-(benzofuran-2-yl)-2-(3-(aryl/heteryl)-5-(aryl/heteryl)-4,5-dihydro-1H-pyrazol-1yl)thiazole derivatives.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1-(Benzofuran-2-yl)-2-bromoethan-1-one
• dihydropyrazolylthiazoles
• multicomponent reaction

Acknowledgments

The authors acknowledge the Director, National Institute of Technology-Warangal for providing the research facilities. One of the authors, Varun Arandkar acknowledges University Grants Commission, New Delhi for providing him with research fellowship.

Additional information

Funding

This work was supported by University Grants Commission-New Delhi: [Grant number F. 2-9/2005(SA)].