Montmorillonite K10-catalyzed synthesis of N-fused imino-1,2,4-thiadiazolo isoquinoline derivatives

ABSTRACT

A novel synthesis of N-fused imino-1,2,4-thiadiazolo derivatives is described. This approach involves the inexpensive, nontoxic, recoverable, and easy to handle montmorillonite K10 that catalyzes the coupling of 3-aminoisoquinolines and phenylisothiocyanates to afford the N-fused imino-1,2,4-thiadiazolo isoquinoline motifs in exemplary yields. The main attractions of this synthetic strategy were simple procedure and excellent yields.

GRAPHICAL ABSTRACT

KEYWORDS:

• Isoquinoline
• isothiocyanate
• montmorillonite
• pyridine
• thiadiazole

Additional information

Funding

The authors acknowledge the financial support from the Department of Science and Technology - Science and Engineering Research Board (DST-SERB), India, under Fast Track Young Scientist Scheme in the form of major research project (No. SB/FT/CS-028/2013 dated: 09.06.2014, 24.09.2015 and 12.09.2016).