Wang resin-supported sulfonic acid-catalyzed multicomponent reaction in water leading to 4-oxo-4,5,6,7-tetrahydroindole derivatives

ABSTRACT

A greener approach for the synthesis of 4-oxo-4,5,6,7-tetrahydro indole derivatives has been achieved through Wang-OSO₃H-mediated three-component reaction involving dimedone, phenacyl bromide, and primary amine in water. A variety of indole derivatives were prepared using this operationally simple and straight forward methodology in acceptable yields.

GRAPHICAL ABSTRACT

KEYWORDS:

• Dimedone
• multicomponent reactions (MCR)
• phenacyl bromide
• tetrahydro indoles
• Wong-OSO₃H

Additional information

Funding

The authors would like to thank Dr. H. Rama Mohan and the management of Dr. Reddy’s Laboratories Limited for giving support to perform this work. We also thank the analytical department of Dr. Reddy’s Laboratories for providing a timely support.