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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 13
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Original Articles

Synthesis of pyrazolopyrimidinones as sildenafil derivatives and sclerotigenin

, , &
Pages 1678-1687 | Received 06 Jan 2018, Published online: 08 Jun 2018
 

ABSTRACT

A series of novel pyrazolo pyrimidinone derivatives (3(a–d), 4(a–d), and 6(a–d)) was synthesized from various pyrazolo amides (2a–d) which are synthesized by the reaction between ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) and various lithium amides. In addition, we also described the synthesis of sclerotigenin drug molecule which has quinazoline moiety from simple 2-nitro benzoic acid with high yields.

GRAPHICAL ABSTRACT

Additional information

Funding

Financial support was provided by a grant from the National Research Foundation of Korea (NRF-2014R1A5A1011165) funded by the Korean Government, through the Center for New Directions in Organic Synthesis.

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