Generation of 4-iodoisocoumarins through a TBAI-mediated oxidative cyclization of 2-alkynoates

Abstract

A tetra-butylammonium iodide (TBAI)-mediated oxidative iodocyclization of 2-alkynoates for the synthesis of various 4-iodoisocoumarin is described herein, and the reaction is highly efficient and shows broad functional group tolerance. This newly developed reaction uses a mixture of water and DCE as co-solvent, and avoids the use of iodine as iodine source for the electrophilic halocyclization.

Graphical Abstract

Keywords:

• 2-Alkynoate
• 4-iodoisocoumarin
• electrophilic iodocyclization
• Oxone

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Corrigendum

Additional information

Funding

We thank the Natural Science Foundation of Jiangxi Province in China [No. 20161BAB213072] and the Scientific Research Fund of Jiangxi Provincial Education Department in China [No. GJJ150326] for their financial support.