A novel dual-nano assisted synthesis of symmetrical disulfides from aryl/alkyl halides

Abstract

Here, we have reported a novel approach towards dual-nano assisted synthesis of disulfides from coupling of alkyl/aryl halides and sulfur nanoparticles. The indium oxide nanoparticles as catalyst expedite the conversion and sulfur nanoparticle notably enhances the miscibility, providing a faster, high yielding and cost-effective process in ethanol-water system. The method has synthetic advantages in terms of mild reaction framework, catalyst regeneration, and absence of any sulfide or polysulfide linkage as by-product leading to a column free synthesis. A variety of alkyl, aryl and heteroaryl symmetrical disulfides are obtained in good to excellent yields up to exceeding 98%.

Graphical Abstract

Keywords:

• Column-free separation
• disulfide
• dual-nano
• green synthesis
• recycle

Acknowledgements

The authors acknowledge Tezpur University, IIT Kharagpur, NEIST, Jorhat and NIT Rourkela for spectral analysis and characterization.

Declaration of interest

No potential conflict of interest was reported by the authors.