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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 15
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Research Article

Naturally occurring bioactive 5-ethylidenehydantoins as inspiration for the development of analogues

, , , , , , , , & show all
Pages 1939-1944 | Received 09 Sep 2017, Published online: 09 Jul 2018
 

Abstract

Many naturally occurring 5-ethylidenehydantoins and their derivatives exhibit extensive biological activities; this characteristic has inspired us to prepare analogues. Fourteen such analogues with the core structure of 5-ethylidenehydantoin were synthesized from readily available components with yields of up to 82%.

Graphical Abstract

Acknowledgements

The authors thank Jiujiang University and Jiangxi Province for financial support of this work. This work was supported by Jiujiang University, the grant number is 8879562.

Disclosure statement

The authors declare no competing financial interests.

Supporting Information

Complete experimental details, 1H and 13C NMR spectra, HRMS and IR data, and information regarding materials can be found in the “Supplementary Content” section of this article’s webpage.

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