New eco-friendly procedure for the synthesis of 4-arylmethylene-isoxazol-5(4H)-ones catalyzed by pyridinium p-toluenesulfonate (PPTS) in aqueous medium

Abstract

In this work we describe a new, highly efficient method for the synthesis of 3-methyl-4-arylmethylidene-isoxazol-5(4H)-one derivatives by a three-component reaction between aromatic aldehydes, ethyl acetoacetate, and hydroxylamine hydrochloride under the influence by PPTS as a low-toxicity, inexpensive, commercially available and easy to handle catalyst. The advantages of this procedure are good yields, short reaction times, simplicity of implementation, and respect of the environment.

Graphical Abstract

Keywords:

• Aqueous media
• eco-friendly method
• 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones
• PPTS
• three-component reaction

Additional information

Funding

The study received financial support from the Algerian MESRS (Ministère de l’Enseignement Supérieur et de la Recherche Scientifique).