One-pot multicomponent synthesis of novel thiazol-2-imines via microwave irradiation and their antifungal evaluation

Abstract

Microwave-assisted green approach is developed for an efficient synthesis of thiazol-2-imines under catalyst-free conditions. The desired products are formed by one-pot three-component reaction which is an improvised method for Hantzsch thiazole synthesis. The microwave-assisted protocol gives excellent yields with high purity in just 10–15 min. All the synthesized compounds have been screened for antifungal activity and some of the derivatives show a broad spectrum against fungal pathogens.

Graphical Abstract

Keywords:

• 1,2,4-Triazolone
• antifungal activity
• green synthesis
• multicomponent reaction
• thiazol-2-imines

Acknowledgments

The authors are grateful to the University Scientific Instrumentation Centre (USIC), Karnatak University, Dharwad and Indian Institute of Science (IISc), Bengaluru, India for providing the spectral data and facility to conduct the experiments. The authors acknowledge the NGH College of Dental Sciences Belgaum, Karnataka, India for antifungal activity.

Additional information

Funding

The authors are thankful to UGC, New Delhi for providing financial assistance under UGC-UPE thrust area ‘‘Antitumor activity: An Integrated Approach’’ vide [F. No. 14-3/2012(NS/PE) Dated: 14-03-2012]. One of the authors Saba Kauser J. Shaikh acknowledges UGC, New Delhi, India for awarding RFSMS Fellowship vide No. F.25-1/2013-14(BSR)/7-100/2007(BSR), Dated 30/05/2014.