Efficient, mild synthesis of N-unsubstituted 1,2,3-triazoles from methanolysis of 1-sulfonyl-1,2,3-triazoles

Abstract

A small library of diverse N-unsubstituted 1,2,3-triazoles was prepared from the corresponding 1-sulfonyl-1,2,3-triazoles, which were treated only with MeOH at reflux temperature. This process was carried out in good yields showing high efficiency and good functional group tolerance.

Graphical Abstract

Keywords:

• N-Unsubstituted 1,2,3-triazoles
• methanolysis
• 1-sulfonyl-1,2,3-triazoles

Acknowledgments

The authors would like to thank Signa S.A. de C. V. for some graciously donated solvents and reagents and to N. Zavala, A. Nuñez, and L. Triana for the technical support.

Additional information

Funding

Financial support from CONACYT (Project No. 135053) is gratefully acknowledged.