Resolution of racemic Vigabatrin using tartaric acid

Abstract

An efficient and simple resolution methodology for the preparation of (S)- and (R)-Vigabatrin has been developed. In addition, a method of preparation for the novel compounds Vigabatrin-l-tartarate and Vigabatrin-d-tartarate is also described. The title compounds have been synthesized via resolution of Vigabatrin using commercially available l-(+)- and d-(−)-tartaric acids respectively.

Graphical Abstract

Keywords:

• (R)-vigabatrin
• (S)-vigabatrin
• resolution
• vigabatrin-d-tartarate
• vigabatrin-l-tartarate

Acknowledgements

The authors are grateful to Aurobindo Pharma Limited for supporting the work. The authors are also thankful to the Chemical Research Department and Analytical Research Department for the support and fruitful co-operation.