Abstract
A concise synthesis of both enantiomers of γ-valerolactone has been developed from commercially available Alanine. The key steps in the synthesis of these γ-Lactones are DIBAL-H reduction of ester (9) followed by in situ Wittig reaction with EtO2CCH = PPh3 ylide (13) (Z/E = 1: 3.5) and one pot lactonization triggered by deprotection of O-TBS ether (14).
Graphical Abstract
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Acknowledgments
The authors would like to thank Dr. H. Rama Mohan and Dr. Reddy’s Laboratories for the support and encouragement. They also would like to thank analytical department of Dr. Reddy’s Laboratories Ltd. for providing analytical support.