MgSiO₃ NPs catalyzed intramolecular cycloaddition reaction: A simple and stereoselective synthesis of unprecedented julolidine analogs

Abstract

A new julolidine hybrid analogs have been accomplished in a regio and stereo controlled manner using heterogenous MgSiO₃ nanoparticles (NPs) catalyzed intramolecular dipolar cycloaddition reaction as a key step. The synthesized catalyst was used in the preparation of various new julolidine analogs with a good yield ranging from 65 to 85%. Further, catalyst could be recycled in several times without loss of significant activity which was an added advantage to the principles of green chemistry.

GRAPHICAL ABSTRACT

Keywords:

• 1,3-Dipolar cycloaddition
• julolidine
• l-proline
• MgSiO₃NPs
• sarcosine

Disclosure statement

No potential conflict of interest was reported by the authors.

Supporting information

Experimental data and characterization of all new compounds.

Additional information

Funding

The authors express their gratitude to RFTT scheme of VGST, Govt of Karnataka and Fast-Track scheme of DST-SERB for financial support. This work was also supported by Department of Science and Technology, Ministry of Science and Technology.