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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 18
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Articles

A one-pot three-component synthesis of fused Spiro-Indoline/Indene derivatives derived from ethynyl azaindole by 1,3-dipolar cycloaddition reaction

Manjunatha NarayanaraoEast Point College of Engineering and Technology, Visvesvaraya Technological University, Bangalore, India; View further author information
,
Lokesh KoodlurDepartment of Studies and Research in Chemistry, Vijayanagara Sri Krishnadevaraya University, Bellary, India; Correspondence[email protected]
View further author information
,
Subramanya GopalDepartment of Studies and Research in Chemistry, Vijayanagara Sri Krishnadevaraya University, Bellary, India; View further author information
,
Suman Y. ReddyApotex Research Pvt Ltd, Bangalore, IndiaView further author information
&
Susmita KamilaEast Point College of Engineering and Technology, Visvesvaraya Technological University, Bangalore, India; Correspondence[email protected]
View further author information
Pages 2441-2451 | Received 10 May 2018, Published online: 08 Oct 2018
 
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Abstract

A one-pot method for the simple, efficient, and environmentally benign protocol for the synthesis of Spiro-Indoline/Indene derivatives containing Aza indole moiety as a side chain is outlined. The 1,3-dipolar cycloaddition reaction of azomethine ylides derived from ethynyl Azaindole under mild conditions is accomplished. The low cost, easy availability of the starting material, and simple reaction conditions suggest the possible use of the present method for large-scale preparations.

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Acknowledgments

Manjunath Narayanarao is grateful to VTU for providing the necessary facility to carry out this work. Authors also acknowledge VSK University for Analytical Support of the title compounds.

Additional information

Funding

This work was supported by Science and Engineering Research Board, [SR/FST/CSI-003/2016].

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