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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 19
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Research Article

Focused microwave irradiation-assisted synthesis of N-cyclohexyl-1,2,4-oxadiazole derivatives with antitumor activity

Valentina Nascimento Melo de OliveiraLaboratório de Síntese de Compostos Bioativos, Departamento de Química, Universidade Federal Rural de Pernambuco, Dois Irmãos, Brazil; ;Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Brazil; View further author information
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Franciane Gonçalves dos SantosLaboratório de Síntese de Compostos Bioativos, Departamento de Química, Universidade Federal Rural de Pernambuco, Dois Irmãos, Brazil; View further author information
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Vanessa Pinheiro Gonçalves FerreiraLaboratório de Oncologia Experimental, Núcleo de Pesquisa em Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceará, Fortaleza, Brazil; ;Oswaldo Cruz Foundation (Fiocruz), Eusébio, BrazilView further author information
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Héverton Mendes AraújoLaboratório de Oncologia Experimental, Núcleo de Pesquisa em Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceará, Fortaleza, Brazil; ;Oswaldo Cruz Foundation (Fiocruz), Eusébio, BrazilView further author information
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Cláudia do Ó PessoaLaboratório de Oncologia Experimental, Núcleo de Pesquisa em Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceará, Fortaleza, Brazil; ;Oswaldo Cruz Foundation (Fiocruz), Eusébio, BrazilView further author information
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Roberto NicoleteLaboratório de Oncologia Experimental, Núcleo de Pesquisa em Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceará, Fortaleza, Brazil; ;Oswaldo Cruz Foundation (Fiocruz), Eusébio, BrazilView further author information
&
Ronaldo Nascimento de OliveiraLaboratório de Síntese de Compostos Bioativos, Departamento de Química, Universidade Federal Rural de Pernambuco, Dois Irmãos, Brazil; Correspondence[email protected]
View further author information
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Pages 2522-2532 | Received 21 Jun 2018, Accepted 05 Aug 2018, Published online: 08 Oct 2018
 
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Abstract

A facile synthesis of 3,5-disubstituted 1,2,4-oxadiazole derivatives under focused microwave irradiation (FMWI) is reported. Arylamidoximes 1a–i and dicyclohexylcarbodiimide (DCC) were carried out in DMF under FMWI to obtain 1,2,4-oxadiazoles 2a–i in 61–81% yields. All compounds exhibited antiproliferative activities in vitro against three human cancer cell lines HCT-116, PC-3, and SNB-19.

Graphical Abstract

Acknowledgment

Our tanks are extended to Analytical Centers CENAPESQ-UFRPE and DQF-UFPE.

Additional information

Funding

This work was supported by the National Council for Scientific and Technological Development – CNPq under Grant number 448082/2014-4; CAPES; and FACEPE-PRONEM under Grant number 0741.106/14.

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