Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are known for inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Diclofenac and its analogs, having phenylacetic acid moiety, are important NSAIDs. In this review article, various methodologies developed after 90 s for the synthesis of various analogs/derivatives of diclofenac sodium have been discussed and summarized.
Graphical Abstract
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Acknowledgments
The authors are thankful to Government College University Faisalabad, UET Lahore FSD Campus and Higher Education Commission, Pakistan for providing facilities to carry out this work.