A simple and mild Suzuki reaction protocol using triethylamine as base and solvent

Abstract

A simple and mild protocol for the palladium-catalyzed Suzuki reaction of aryl bromides and arylboronic acids is developed. The cross-coupling reactions can be performed at room temperature using 5.0 equiv. of Et₃N as solvent and base without any ligands, and affording biaryl products in good yields. In addition, the chemoselecitive Suzuki reaction of bromo-N-methyliminodiacetic acid (MIDA) boronates with arylboronic acids can be achieved in this system, and various unsymmetrical terphenyls have been prepared in moderate yields by one-pot double Suzuki reactions.

GRAPHICAL ABSTRACT

Keywords:

• Ligand-free
• one-pot
• Suzuki reaction
• terphenyls
• triethylamine

Additional information

Funding

We are grateful for the grants from NSFC (Nos. 81660575 and 81360471), and the Scientific Research Foundation of Zunyi Medical University (E-234, F-807), the Natural Science and Technology Foundation of Guizhou Province [2018]1187.